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We compared human aortic smooth muscle cells (HASMCs) with and without CRISPR-Cas9 editing of the Loxl2 gene (HASMC T1) to test whether LOXL2 depletion correlates with loss of BHZ incorporation signal and to determine the specificity of the assay

workers in industries (e.g., paper or herbicides and pesticides industries), people who live near the industries, and certain people are more vulnerable to dioxin toxicity like children, pregnant women, breastfed infants, and those with a lower socioeconomic status because they lived in poor or highly industrialized contaminated areas (Weir 2005

The molecule providing a polar hydrogen for a hydrogen bond is called a donor

In combination with osteoclast activation induced by urate crystals, these processes lead to progressive destruction of periarticular soft tissue, joint deformity, and the characteristic punched-out bone erosions observed in late-stage gouty arthritis (176)

This can result in faster onset of action and increased efficacy of the medication