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A 2016 comprehensive review published in CNS & Neurological Disorders Drug Targets found that numerous studies show SAM-e affecting critical components involved in the pathophysiology of major depressive disorder, and several randomized controlled trials have supported that S-adenosylmethionine is superior to placebo and tricyclic antidepressants

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A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system

Potential immunotherapeutic strategies for COVID-19 As discussed above, there is strong evidence supporting a close association between SARS-CoV-2-induced immunopathology and poor survival of patients with COVID-19