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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)

J.LiX.SunL.GuoJ

17.6% of these studies were performed in the US

Liu X, Chen Z

coli revealed that at least some loss of ATP upon HOCl stress is due to conversion of cellular ATP to inorganic polyphosphates (polyP), which by themselves can act like ATP-independent chaperone holdases, effective in stabilizing unfolding proteins and preventing protein aggregation both in vivo and in vitro [282, 283] (Fig