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Figure 1 3.1 Autoimmune and inflammatory responses in GD increase the risk of depression GD is a common autoimmune disease in which excessive production of stimulatory autoantibodies disrupts critical physiological processes inside and outside the thyroid gland in GD, resulting in cellular and humoral immune disorders (26)

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A recent insert-based lung model incorporating epithelial-alveolar macrophage co-cultures have demonstrated that macrophages modulate epithelial cell function under cigarette smoke exposure, mimicking in vivo inflammatory dynamics and macrophage polarization shifts 10

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