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As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)

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GSH was associated with cell-cycle activation in cell suspension cultures, whereas hGSH was associated with differentiated cells (Pasternak et al., 2014)

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Genomic characterization of metastatic breast cancers