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Nat Rev Dis Primers 3 , 17040 (2017)

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5-Amino-1MQ inhibits NNMT activity, preserving nicotinamide for NAD+ synthesis and preserving SAM for epigenetic methylation producing a metabolic state in pre-clinical models that has been described as functionally resembling caloric restriction or elevated physical activity at the cellular level

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2.2 Departure times and routes are subject to change without prior notice