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10.1016/j.metabol.2018.01.013 141 YanW.ChenY.GuoY.XiaY.LiC.DuY.et al (2022)

This cellular and molecular damage accelerates the aging process, driving the onset of age-related diseases such as cardiovascular disorders, neurodegenerative diseases, diabetes, and inflammatory conditions

In each group, 30,000 cells were initially analysed using FACS and 21,00024,000 cells were eventually included in statistical analysis

IGF-1R activates various intracellular secondary messenger pathways upon binding its ligands (IGF-1, IGF-2, and insulin at supraphysiological concentrations)