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There are three prevailing mechanisms involved: firstly, phosphorylation of the intracellular terminus of CD44 occurs following its interaction with HA and subsequent activation by protein kinase c (PKC) ( Figure 2 ) ( Figure 2 CD44 can synergistically interact with VLA-4 integrins through intracellular signaling pathways, aside from its significant adhesion role ( Lipid rafts are cholesterol- and sphingolipid-rich microstructural domains in the plasma membrane ( Paxillin, an adhesive patch adaptor protein, is mainly localized at focal adhesions (FAs) ( 2.2 Mechanisms involved in growth and proliferation survival CD44 is capable of binding to ligands to activate a range of intracellular signaling pathways that regulate cellular growth, proliferation, survival and various other activities

Dose splitting Some providers recommend splitting the weekly dose into two smaller injections given 3 to 4 days apart

Primers for GAPDH and were used for normalization

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request