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Tolerogenic dendritic cells modified by tacrolimus suppress CD4 + T-cell proliferation and inhibit collagen-induced arthritis in mice

These may directly affect the healing repair of connective tissues [18,19,20,21,22], presenting NO-system directly related to skeletal muscle and tendon and muscle and tendon injuries, and considering the essential role of NO in healing [39,77] as an ordered multistage process involving inflammation and oxidative stress [78]

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Animals were raised in a pathogen-free environment in the Animal Laboratory of China Medical University and have obtained ethical approval from the Institutional Review Committee of China Medical University (ethical batch number: 2018127) for all in vivo experiments