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Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors

Specifically, the Cd accumulations in the 50 and 100 mg kg 1 GSH treatments were 1.66- and 1.67-fold higher in the roots and 1.29- and 1.71-fold higher in the shoots than in the treatment with Cd alone, respectively (Figure 1B)

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This was due to longer plasma presence and more BBB crossing routes, including clathrin- and caveolae-mediated endocytosis