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Less common B12 shot side effects include : Chest tightness Skin rash or hives Dizziness Difficulty breathing A blue tint to the skin Call your doc ASAP if you notice any of these negative effects

[1] For example, if a 2 mL dose (full 200 mg thiamine, 200 mg niacinamide) is to be given IV, a nurse might mix it into 50 mL of saline and infuse over 15-30 minutes

The effectiveness of this procedure can be attributed to the combination of effects that it has on the body

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Potential Side Effects and Considerations While vitamin B12 injections are generally safe, some people may experience mild side effects, such as soreness at the injection site or a slight rash