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Acknowledgements The authors would like to sincerely thank the following individuals and institutions who made vital contributions to this study: We thank Rhyad Al-issa from the Department of Biochemistry, College of Medicine, King Khalid University, for his technical support in the preparation of the electron microscopic slides

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For example, a small study with N-acetylcysteine (NAC) infusion reported acute increases in brain GSH concentrations in three healthy older adults (35), while oral doses of NAC have been ineffective (36)

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Graves disease (autoimmune hyperthyroidism) also produces TPO antibodies, though the dominant antibodies in Graves disease are thyroid stimulating immunoglobulins (TSI) rather than TPO antibodies