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The peptide has been associated with mild to moderate side effects, including injection site reactions, headaches, nausea, abdominal pain, and flushing [32]

Also, in the state of metabolic abnormalities, activated RhoA/ROCK pathway may also damage the endothelial function in CC through other pathways such as promoting the release of inflammatory factors and increasing the inflammatory response in vascular endothelial cells [38], as well as persistently impairing endothelial-dependent vasodilation to reduce endothelial NOS activation by inhibiting the insulin receptor substrate-1/phosphoinositide 3-kinase/protein kinase B pathway [39]

Bacteriostatic water contains 0.9% benzyl alcohol, which prevents microbial growth in the multi-use vial over the storage period

This study is reported in accordance with the ARRIVE guidelines

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