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As a result, the wound remains in a prolonged inflammatory phase, which prevents the transition to the proliferative phase, characterized by tissue growth and wound closure

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Advances in Protein Chemistry and Structural Biology

These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

The selective effects of DSIP on the blood supply to the brain explain at least part of this effect