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3.2.1 Berberine clinical application and dosing In clinical trials, berberine typically is administered at 500 mg two to three times daily (11.5 g total per day)

10.1002/pmic.202200039 179 KwizeraE

LncRNA P53RRA can bind to Ras GTPase activating protein binding protein 1 (G3BP1) to activate the p53 pathway and retain more p53 in the nucleus, thereby exerting a pro-ferroptosis effect [170]

Although it has been suggested that metformin treatment may exert a synergistic antitumor effect with ICIs, the study by Jacobi et al (107) did not obtain any positive association between metformin and ICIs in the treatment of patients with diabetes combined with NSCLC