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The inhibitory effect of glucocorticoids on corticotroph POMC expression appears, in the rat POMC promoter, to be dependent on a glucocorticoid response element partially overlapping the CCAAT box (27)

Furthermore, the study hypothesizes a potential interaction of AOD9604 with the beta-adrenergic pathway, especially concerning the beta(3)-adrenergic receptors (beta(3)-AR), which are considered to be key lipolytic receptors found in fat cells

2014 Apr;22(4):1143-51

After adjustment for age and sex, none was significant except the RR of Alzheimer disease associated with a 1-SD increase in the log-transformed level of plasma PC linoleic acid (RR, 1.27 [95% CI, 1.01-1.61