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Although there is limited published evidence explicitly documenting a stronger cultural bias in Asian populations favoring joint preservation over knee arthroplasty, these patients often have higher functional demands for deep knee flexion post-TKA (for example, squatting and kneeling) 140

The effectiveness data available to date together with the basic biology studies most certainly warrant further research into this compound in the conditions discussed here and in clinical scenarios reviewed elsewhere [6]

PhGs show significant hepatoprotective potential through their multi-target mechanisms, addressing critical processes such as oxidative stress, inflammation, apoptosis, and fibrosis

For instance, GPX4 palmitoylation by ZDHHC20 enhances its stability, while APT2-mediated depalmitoylation promotes ferroptosis in colorectal cancer and metastasis models (61)

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