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Details of the assessment method can be referred to previous reports 60

152,153 Moreover, intracellular copper can stabilize the biochemical structure of transcription factor HIF-1 and enhance the activity of the nuclear factor NF-B, thereby ensuring their transcriptional activity on angiogenesis genes such as VEGF and ceruloplasmin and promoting the expression of angiogenic mediators including FGF2, VEGF, IL-8, IL-6, and IL-1

Effect of methylphenidate on apathy in patients with Alzheimer disease: The ADMET 2 randomized clinical trial

Mrida, S., et al