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Individual participant data will be shared in datasets in a de-identified and anonymized format

Resistance when drawing or injecting If the solution seems thicker than usual, requires more pressure to draw into the syringe, or feels different during injection, aggregation may have increased the viscosity

Initial treatments may require several injections per week, followed by maintenance doses every month

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)

A long-term efficacy study published in the Journal of Headache Pain in 2018, that followed patients for two years showed similar results