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COX-2 inhibition impairs mechanical stimulation of early tendon healing in rats by reducing the response to microdamage

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After 24 h of intranasal administration of a proinflammatory dose of LPS (100 ng per mouse), robust neutrophil infiltration was observed in the lungs compared to the PBS group, and comparable numbers of neutrophils were detected in both bronchoalveolar lavage fluid (BALF) and lung homogenates of WT and XKR8 KO mice (Extended Data Fig