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McFarland LV, Dublin S

Recent studies have showed that oral ingestion of L-carnitine in both animals and humans results in generation of trimethylamine by intestinal microbiota, which is absorbed and then metabolized to trimethylamine-N-oxide (TMAO) by liver flavin monoxygenases (FMOs) (especially FMO3 and FMO1) 35 , 45

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Similarly, another Phase II trial (NCT00265148) investigating rosiglitazone XR observed a modest improvement in Cerebral metabolic rate of glucose (CMRglu) over 12 months (treatment: 6.3%, placebo: 13.1%

Based on the data available, the association between eight Indian spices (black cumin, black pepper, curry leaf tree, fenugreek, fennel, coriander, cumin, and cardamom) and several age-related neurological diseases such as Parkinsons disease, Alzheimers disease, dementia, epilepsy, multiple sclerosis, cerebrovascular disorders, traumatic brain injury, Huntingtons disease, and brain tumor was summarized