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The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework

Variability between genetically distinct populations Certain cell surface proteins exhibit a genetically determined high degree of inter-donor variability in expression, including CR1 and complement molecules C4A and C4B 31,32

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA

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