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Beside scavenging free radicals and recycling the other antioxidants, glutathione is needed for phase 2 liver detoxification and also plays a very important role in immune function, specifically the specialized immune cells of the brain, called glial cells

Genetic induction of ferroptosis in a small fraction of K14 + KCs in mouse epidermis via the deletion of Gpx4 was sufficient to initiate and maintain a phenotype with cutaneous and systemic inflammation closely resembling psoriasis, and to activate canonical signaling pathways and multiomics biomarkers linked to the disease

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While L-glutamine was approved by the United States (US) Food and Drug Administration to treat SCD, its impact on the redox environment in sickle erythrocytes is not fully understood

Br J Cancer (suppl.) 6: 5560