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Nat Rev Neurol (2015) 11(12):71124

Lrig1-expression confers suppressive function to CD4 + cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

In addition, we have some evidence that beta-mercaptoethanol and MgCl2 may have an impact on the cobalt as well

In the same study, they also showed that after chronic Mn injection (daily for 30 days) in mice, there was a reduction in TH-positive cells in the substantia nigra