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Beyond oxygen production, MnO nanoparticles possess intrinsic immunomodulatory activity: they can reprogram TAMs from an immunosuppressive M2 phenotype to a pro-inflammatory M1 phenotype, effectively reversing the immunosuppressive nature of the TME [285]

Its levels drop dramatically when the toxic load is large Detoxifies many xenobiotics Chelator of lead, mercury, cadmium, and arsenic Prevents neuropathy from chemotherapy Maintains reduced state of other antioxidants: vitamin C & E Supports numerous metabolic and biochemical reactions: DNA synthesis and repair Protein synthesis Prostaglandin synthesis Amino acid transportation Enzyme activation Glutathione is a powerful antioxidant made in the bodys cells, using amino acids: glutamine, glycine, and cysteine

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El-Agroudy NN, Kurzbach A, Rodionov RN, OSullivan J, Roden M, Birkenfeld AL, et al