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CMH@lip@Res-TCeO 2 modulates the ROS/mTOR/HIF-1 axis to promote neutrophil metabolic reprogramming and inhibit NETs formation Neutrophils were isolated from the skin of IMQ-induced psoriasiform mice and treated with CMH@lip (blank liposomes), CMH@lip@TCeO 2 , CMH@lip@Res, CMH@lip@Res-TCeO 2 , or CMH@lip@Res-TCeO 2 combined with MHY1485 (Fig

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Anti-GPX4 antibody and propidium Iodide flow cytometry kit were purchased from Abcam (Cambridge, MA, USA)

10.1016/S0014-5793(99)01768-8 96 VanackerH.CarverT

Hydroxocobalamin binds more tightly to serum proteins, creating a depot effect that allows for slower release and prolonged availability to tissues