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The strongest human evidence is for the intranasal route : small Russian clinical trials in generalized anxiety and neurasthenia reported anxiolytic effects comparable to medazepam , but without the sedation or dependence typical of benzodiazepines [1] [2]

For the Foetus Neural Tube Defects : Vitamin B12 deficiency during pregnancy can trigger neural tube defects in the unborn baby, which may affect his spinal cord and brain

Onset & Duration: Injectable forms can provide a more immediate uptick in concentration, potentially influencing sleep onset more aggressively

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Its important to know that cortisone can cause a flare of pain in the first few days before it helps (more on that below), so you should rest for a few days after the shot