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Reactive astrocytes interact with microglia/macrophages and initiate the formation of the scar-border via secretion of extracellular matrix proteins, such as laminin, fibronectin and chondroitin sulfate proteoglycans (CSPGs) (Sofroniew, 2009

But in general, these folks are more likely to be B12 deficient: vegetarians or vegans people taking certain medications (like metformin, Prilosec, or Pepcid) pregnant and breastfeeding people people over 50 people with atrophic gastritis, celiac disease, Crohns disease, or who have had stomach or intestinal surgery Which form of vitamin B12 is best

What to look for in a vendor Third-party testing: Legitimate vendors provide Certificates of Analysis (COA) from independent labs showing purity above 98% and accurate peptide content 503B pharmacy status indicates the pharmacy operates under FDA oversight with more stringent quality controls than 503A pharmacies Proper shipping: The vial should arrive in insulated packaging

Yin et al., 2022

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