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Some individuals report feeling overstimulated with high-dose supplementation, though these reports are anecdotal and not supported by controlled studies

Untreated hypothyroidism can raise cholesterol by 20-50 mg/dL and increase heart disease risk, while severe hyperthyroidism may trigger life-threatening thyroid storm with heart rates exceeding 140 bpm

While the scientific evidence is unclear, adequate levels of B12 help the body produce melatonin, a hormone crucial for regulating our circadian rhythms and promoting a good nights sleep

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The sulfur-containing amino acids. J Nutr