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for instance, isoalloLCA enhances Treg differentiation via VDR-independent pathways involving mitochondrial ROS or NR4A1 ( Furthermore, VDR signaling pathways exhibit direct molecular crosstalk and functional competition with other key nuclear receptors sensing BAs and xenobiotics

If the DNA is not replicated properly (mismatches), MLH1, MSH2, MSH6 and PMS2 work together to repair the abnormality

Microglia can change from pro-inflammatory (M1-like) to anti-inflammatory or reparative (M2-like) phenotypes, demonstrating their extraordinary adaptability

Furthermore, the Cys15 and Cys170 residues could require a PAT for palmitoylation, and therefore would only be modified by palmitate within cells, and not in vitro

doi:10.1096/fj.09-132795