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The long-term component is motivated by cohort studies indicating that chronic tinnitus patients carry an increased risk of subsequently developing AD and PD (adjusted hazard ratios of 1.54 and 1.56, respectively) (Chu et al., 2020)

NNMT (Nicotinamide N-Methyltransferase) is a cytosolic enzyme that catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide producing 1-methylnicotinamide (1-MNA) and S-adenosyl-homocysteine (SAH) as reaction products

In a previous study from our laboratory and others demonstrated that SR-BI expression is transcriptionally regulated via estrogen and estrogen deprivation down-regulates SR-BI expression 41

Of course, beyond antioxidant-specific interventions, it is essential to address the upstream metabolic triggerchronic hyperglycemia