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Pen Dosage Chart Dosage & Protocols Variations Standard Research Protocol Dose: 0.2 0.4 mg (variant 5 mg pen = 816 clicks / variant 10 mg pen = 48 clicks) Duration: 2 4 weeks Frequency: Daily Cycle Interval: 2 4 weeks off before repeating Goal / Description: Common dose for general recovery models

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The authors claim this allosteric site has a higher affinity for cocaine than site S1, and that the binding of cocaine in this site induces profound conformational changes inhibiting the binding of dopamine at site S1 (Xu and Chen, 2020)