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Underlying mechanisms are incompletely defined but include intraoperative and postoperative phenomena, such as inflammation, sympathetic activation and cardiac ischaemia, that combine to trigger atrial fibrillation, often in the presence of pre-existing factors, making the atria vulnerable to atrial fibrillation induction and maintenance

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Additionally, DOPA decarboxylase (DDC) enzyme inhibitors, dopamine agonists (DA), monoamine oxidase B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, and centrally acting anticholinergics are employed to modulate dopaminergic/cholinergic signaling and improve quality of life