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In NSCLC, recent reports suggest that human lung cancer cell growth can be inhibited by GPX4-related ferroptosis, a type of cell death characterized by lethal accumulation of lipid-based ROS 17,18

& Rougny, A

1, 2 This impairment appears to play a role in the pathogenesis of migraines, since two different nutrients that are essential for mitochondrial energy production (i.e., riboflavin 3 and magnesium 4 ) were each shown in randomized controlled trials in the 1990s to be effective for migraine prophylaxis