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Among these, endothelial dysfunction and vascular remodeling are central to both disease initiation and progression

Xiao Z, Shen D, Lan T, Wei C, Wu W, Sun Q, et al

Thermogenic activation induces FGF21 expression and release in brown adipose tissue

Free SH groups as in reduced GSH, are essential for the activity of all metabolite carriers in the inner mitochondrial membrane, otherwise, extensive thiol oxidation results in: the inhibition of transport activity, and the dissipation of the mitochondrial inner transmembrane potential ( [ ]), an early, potentially reversible event observed in mitochondrial related apoptotic processes, bioenergetic failure, also an early event that is part of the dissipation of [ ], and an increase in the permeability of the mitochondrial membrane, a later event in mitochondrial related apoptotic processes

Calpain-independent intracellular protease activity is elevated in excitotoxic cortical neurons prior to delayed calcium deregulation and mitochondrial dysfunction