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Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

Muffley LA, Zhu KQ, Engrav LH, Gibran NS, Hocking AM (2011) Spatial and temporal localization of the melanocortin 1 receptor and its ligand -melanocyte-stimulating hormone during cutaneous wound repair

The peptide improves hydration, increases elasticity, repairs barrier proteins, and corrects mottled hyperpigmentation

Higher dosing or longer cycles use more compounded medication

Results Figure 1 shows the anatomical distribution of the major pelvic ganglia, the CNs and the communicating nerve branches to the DPNs in the rats