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Discussion DR is a leading global cause of blindness [35], primarily due to its complications, such as PDR and diabetic macular edema (DME) [36]

N Engl J Med 2012;367, 795804, doi: Guerreiro, R

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Neuropsychopharmacology 37:23322344 Bertran-Gonzalez J, Laurent V, Chieng BC, Christie MJ, Balleine BW (2013) Learning-related translocation of delta-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions

Whether these approaches work as intended remains uncertain, but the theoretical basis makes sense