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In the kidney, elevated ROS levels contribute to pathological changes such as glomerulosclerosis, tubular atrophy, and interstitial fibrosis, primarily through the activation of pro-inflammatory and pro-fibrotic signaling pathways, such as NF-B and TGF- (71)

More than 20 circRNAs have been reported to inhibit ferroptosis by acting on GPX4, system Xc-, FSP1, lipid metabolism, and other pathways and play important regulatory roles in the progression of many diseases, including various cancers, diabetic nephropathy, polycystic ovary syndrome, and myocardial infarction

Recently, the potential activity of AGE to ameliorate cognitive impairment has attracted some interest

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