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Wilsons disease: clinical management and therapy

This combination may provide an effect equal (additive), greater (synergistic), or less (antagonistic) than the sum of the individual component effects

Moreover, the use of small molecular oral agents to inhibit this pathway as opposed to biologic inhibitors of cytokines, makes this approach even more appealing

Administration of oxidizing drugs such as those of the sulfa class can lead to weakening of erythrocyte plasma membranes due to rapid depletion of reduced glutathione levels and inadequate NADPH-dependent reduction of the oxidized form.

In a human study Clinical Glutathione was found to improve the ratio of active form of glutathione (reduced glutathione) to the inactive form (oxidized) in the body by 230%