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Beta-side amyloid precursor protein cleaving enzyme (BACE1) is more active and has a greater protein level in brain tissue associated with AD, which is closely connected to the pathophysiology of AD

Cancer Sci 99:816823

Mirza H, Kamrun N, Gill SS, Alharby HF, Razafindrabe B, Masayuki F (2017) Hydrogen Peroxide Pretreatment Mitigates Cadmium-Induced Oxidative Stress in Brassica napus L.: An Intrinsic Study on Antioxidant Defense and Glyoxalase Systems

Senolytic treatment reduces oxidative protein stress in an aging male murine model of post-traumatic osteoarthritis

At therapeutic IV doses (often 2550 g in oncology and critical-care research), studies report improvements in inflammation markers, oxidative stress, and quality of life in advanced cancer and sepsis, although evidence is strongest for adjunctive rather than standalone use