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In the state of sepsis, the reprogramming of tryptophan metabolism is mainly manifested by the activation of the kynurenine pathway, and its metabolites play an immunomodulatory role by inhibiting T-cell activation and proliferation, thereby reducing excessive inflammatory responses (172)

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Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjogrens syndrome

As mentioned, enrichment of the oropharyngeal microbiome in the lung, such as enrichment of Veillonella and Revotella , was correlated with phenotypes of inflammation, including increased Th17 lymphocyte levels, increased inflammatory cytokine expression, and reduced expression of the inflammatory cytokine TLR4 in alveolar macrophages