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Hydrogel-based in situ vaccines co-delivering cGAMP nanoparticles with ICD inducers demonstrate that ICD-derived signals synergistically enhance STING pathway activation, fostering robust DC and CD8 + T cell responses that suppress tumor progression across immunologically cold tumor models (154, 166)

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219 Although research on the role of inflammation in mitochondrial diseases is still limited, inflammation is a critical factor in many human diseases, such as neurodegenerative disorders