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Female human livers exhibit higher carboxylesterase-1 (CES1) protein abundance and increased in vitro activation rates for several CES1 substrates, including oseltamivir (conversion to oseltamivir carboxylate) and dabigatran etexilate (conversion to dabigatran) (Shi et al

In addition, ginkgolic acids and related alkylphenols, naturally present in ginkgo leaves, are strongly allergenic and cytotoxic

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