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Introduction The relationship between high-density lipoproteins (HDLs) and cardiovascular disease (CVD) is a topic of intense investigation since decades ( Epidemiological studies have shown a correlation between low levels of HDL-cholesterol (HDL-C) and increased incidence of CVD ( Increasing evidence suggests that rather than cholesterol levels present on HDL, HDL particle number, lipid and protein composition play a key protective role in reducing CVD risk ( ECs are a physical barrier between blood and body tissues, which act as gatekeepers of cardiovascular homeostasis