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Through connecting nerves, such as the vagus nerve, bioactive molecules like neurotransmitters and hormones transmit signals between the gut and brain, as well as the immune system

[Updated 2023 Jan 17]

Moreover, most popular cell lines used are cancer-derived or immortalized, and do not represent the primary genomics of healthy cells [49]

Benn CL, Sun T, Sadri-Vakili G et al (2008) Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner