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Transcriptionally, GPX4 expression is promoted by Nrf2 and ATF4 in response to oxidative or endoplasmic reticulum stress

Protein Cell 12 , 426435 (2021)

(1997) reported that IGF-1 LR3 increased tumor growth in tumor-bearing catabolic rats

Under its physiological functional state, Prx2 appears as a monomer (active form) of about 2030 kDa and when interacting with H 2 O 2 , Prx2 is oxidized and a disulfide-linked dimmer is formed (inactive form) [73, 77]