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10 These findings highlight the substantial heterogeneity inherent in PD pathophysiology and support RBD-PD as an aggressive clinical subtype

SPAP plays an important role in inhibiting tumor growth and promoting ferroptosis, but requires a large dose to inhibit SLC7A11, thereby limiting the clinical application of SPAP

Recently, it has been found that physiological doses of CO, produced during the HO-1 enzymatic reaction, can act as intracellular second messengers, promoting mitochondrial regeneration and restoring mitochondrial membrane potential, thereby reducing mitochondrial ROS production (Huang et al., 2018)

A proper dose is often restricted by toxicities including thrombocytopenia and hematotoxicity [21]

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