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Arterioscler Thomb Vasc Biol 17 : 569573

doi: 10.1016/j.foodchem.2016.02.029 179 PerestreloR.SilvaP.Porto-FigueiraP.PereiraJ.SilvaC.MedinaS.et al

This APOE 4 effect was confirmed in a recent study from the same cohort that included a larger sample size (675 mutation carriers and 594 controls), and further reported that the APOE 2 genotype was associated with a delay in age-dependent cognitive decline as compared to non-carriers [190]

Because the condition results directly from retained toxins rather than primary inflammation, standard therapies like nonsteroidal anti-inflammatory drugs or colchicine are ineffective, making hemodialysis the only definitive, life-saving intervention