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(4) Data Source and Reporting This eCQM uses data collected through hospitals' EHRs

This work was supported by grants from the Hainan Province Clinical Medical Center (QWYH202175), the Scientific Research Project of Hainan Health Committee (21A200115), the Research and Cultivation Fund of Hainan Medical University (HYPY2020015), the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202311), the Natural Science Foundation of Hainan Province (820RC771), and the Key R&D Projects of Hainan Province (ZDYF2022SHFZ074)

Cell cytotoxicity assays A total of 1 10 5 cells/well in a 96-well plate were treated as indicated in figure legends or overexpressed with GSDME-NT

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Previously overlooked, direct interference with HIF-1 pathways can lead to a change in the management and outcomes of GBM treatment