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Estrogen helps to balance cortisol, aka the stress hormone, in your body, so when estrogen levels waver and drop, cortisol can rise

Due to the important role of oxidative stress in the pathogenesis of NDs and the susceptibility of the central nervous system (CNS) to oxidative stress, delaying or preventing the degeneration of nerve cells by scavenging ROS or preventing their formation has become one of the promising strategies to prevent and treat NDs

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Yet, p62, a component of this system, is itself a target of carbonylation, as observed in cholestatic liver (141146)